We are funding the only
research chair in Canada
We need your support


Is scleroderma an autoimmune disease?

The role of the immune system is to protect the body from foreign invaders, such as viruses and bacteria. Sometimes, however, this system goes awry and the immune response, which normally targets only outside elements, turns against the body’s own cells, attacking them, resulting in the production of large quantities of autoantibodies. Some studies suggest that scleroderma is an autoimmune disease. The main evidence for this notion is the fact that SSc patients have specific autoantibodies. In the case of scleroderma, fibroblast cells (a type of cell in the body which produces collagen and is important in wound healing) are abnormally overactivated and overproduce collagen that spreads throughout the skin and various internal organs, causing inflammation, leading to tissue fibrosis (scarring). 

Is scleroderma a hereditary disease?

At present, it is unclear what exactly triggers this autoimmune disease. Research is being conducted to find out if there is a genetic susceptibility to scleroderma, but as yet the disease does not appear to be hereditary. There is no direct cure for scleroderma. Because the exact cause is unknown, any treatment is patient-specific and aimed at making symptoms of the disease more tolerable. Thus, it is imperative to continue research to find the underlying causes of this disease, develop new treatments to adequately relieve patients and, ultimately, find a cure that will allow patients to overcome scleroderma.

What are the symptoms of scleroderma?

Thickening and decreased flexibility of the skin of the fingers and other body parts is characteristic of scleroderma. Raynaud's phenomenon is almost always present, although it should be noted that about 4% of the general population also has Raynaud and most of these people will never develop scleroderma. Painful ulcers can occur at the fingertips. The fingers can gradually become fixed in a bent or flexed position. Arthritis (joint pain and swelling) and muscle weakness may also occur. Esophagus involvement can cause heartburn, regurgitation and difficulty swallowing. Small intestine involvement may cause an intestinal obstruction and reduce the ability to absorb food. The lung or heart involvement can cause shortness of breath. The involvement of the kidneys can manifest itself as a severe arterial hypertension crisis and reduced kidney function (renal failure). Some patients have a significant weight loss, while others have a persistent pruritus (itchy skin). Fatigue and decreased ability to carry out daily activities are pervasive. Scleroderma is a major cause of physical and moral suffering and decreased quality of life.

For more answers to your questions, read the F.A.Q.

Discover our Website

Funding of the Scleroderma Research Chair, the only one of its kind in Canada. To learn more about the Chair and how to support it, please click here.

To learn more about our financial support to research, please click here.


A pan-Canadian campaign ready to share!

Abnormal elevation of blood pressure in the pulmonary arteries, also called pulmonary arterial hypertension (PAH, is a serious complication that occurs in one out of six SSc patients. If left untreated, people with PAH live on average two to three years after being diagnosed. We need your help to ensure that Canadians affected by PAH, including those with SSc-PAH, have access to any and all treatments available in Canada. Please visit the pan-Canadian campaign website by clicking here.


Check out our latest publications, available for free download, please click here.


Website last updated on: February 23, 2018

challenge to beat scleroderma through fundraising for research